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Because of these complications, five-year survival rates may be as low as 55 percent.

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Any dramatic or persistent increase in the results of LFTs mandates a series of diagnostic tests to evaluate for possible causes, such as rejection, ischemic insult to the liver (hepatic artery problems), biliary complications, infections (viral hepatitis, bacterial sepsis), or drug toxicities or hypersensitivities.

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Chronic pancreatitis is often presents in adults ages 30 to 40 and in addition to chronic, excessive alcohol use, cystic fibrosis, and hypercalcemia may be caused or precipitated by hyperlipidemia, hypertriglyceridemia, or autoimmune disorders.

HIV-1--infected patients are limited, fibrosis stage is the most reliable means to assess prognosis and provide information for decisions about the need for initiation of therapy.

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Unlike protease inhibitors, which block HIV replication in steps after integration with cellular DNA, all drugs in the recommended regimen (tenofovir, emtricitabine, and either raltegravir or dolutegravir) act before viral integration with cellular DNA, providing a theoretical advantage in preventing establishment of HIV infection.

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The AASLD suggests indefinite antiviral therapy for HBeAg-positive adults with cirrhosis with CHB who seroconvert to anti-HBe on NA therapy, based on concerns for potential clinical decompensation and death, unless there is a strong competing rationale for treatment discontinuation.

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The two groups were comparable in most baseline characteristics, although in the prophylactic lamivudine group, there were significantly more patients with lymphoma and receiving anthracyclines.

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Although not necessary for diagnostic purposes, liver biopsy may be useful to assess the degree of liver damage and determine the need for treatment.

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Such estimates are also useful when creating and improving mathematical models of the different strategies that might be followed to provide ART in LMICs.

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